What is Nephron?
The structure that really makes urine in the process of eliminating waste and excess substances from the circulation is called a Nephron. Each human kidney contains approximately 1,000,000 Nephrons. The most rudimentary Nephrons can be found in primitive fish kidneys (pronephros), amphibian larvae, and embryos of more evolved vertebrates. The Nephrons seen in amphibians’ and most fish’s kidneys (mesonephros), as well as in the late embryonic development of more sophisticated vertebrates, are only marginally more advanced in structure. Adult kidneys, or metanephros, of land vertebrates such as reptiles, birds, and mammals have the most mature nephrons.
Structure of Nephron
In the mammalian kidney, each nephron is a long tubule, or exceedingly fine tube, measuring 30–55 mm (1.2–2.2 inches) in length. This tube is closed, inflated, and folded into a cuplike shape with two walls. The structure of nephron comprises two major portions: Renal Tubule and Renal Corpuscle
The renal corpuscular capsule, also known as Bowman’s capsule, encloses the glomerulus, a cluster of small blood arteries called capillaries. The renal corpuscle is made up of the capsule and glomerulus. Blood travels into and out of the glomerulus via tiny arteries known as arterioles, which enter and exit the glomerulus through the capsule’s open end. Fluid filters out of the blood in the glomerulus via the inner wall of the capsule and into the nephron tubule in the renal corpuscle. The secretion of certain compounds into the filtrate and the selective reabsorption of water and other ingredients from it change its composition as it moves through the tubule. Urine is the final product, which is transported into the renal pelvis via the collecting tubules.
The function of Nephron is dependent on its two major parts:
The renal tubule is a lengthy, convoluted structure that arises from the glomerulus and is separated into three functional segments. Because of its proximity to the glomerulus, the initial section is called the proximal convoluted tubule (PCT), and it remains in the renal cortex. Because it creates a loop (with descending and ascending limbs) that travels through the renal medulla, the second part is called the loop of Henle, or nephritic loop. The distal convoluted tubule (DCT) is the third portion of the renal tubule, and it is similarly limited to the renal cortex.
Bowman’s capsule is a cup-like structure that surrounds the glomerulus’ capillaries. This structure continues to generate PCT tubules, which are highly coiled tubules. PCT continues to form the Henle loop, which leads to DCT, which then leads to the collecting duct. Tubules’ primary role is reabsorption, which can be accomplished through active or passive transport. Tubule secretions also aid in the production of urine without disrupting the body’s electrolyte balance.
A glomerulus is enclosed by a Bowman’s capsule in the renal corpuscle. An afferent arteriole gives rise to the glomerulus, which then empties into an efferent arteriole. The smaller diameter of an efferent arteriole aids in the maintenance of high glomerular blood pressure. There are three levels to Bowman’s capsule:
- The outer parietal layer is made up of epithelial cells with tiny holes of 12nm in width.
- This stratum of the basement membrane is selectively permeable.
- The inner visceral layer is made up of big nucleated cells called podocytes that have podocel, which are finger-like projections.
The diagrammatic representation of Nephron is:
Figure: Diagrammatic Representation of Nephron
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Ques. What are the 3 functions of the Nephron?
Ans. The primary function of the nephron population is to maintain plasma homeostasis and eliminate possible poisons through urine. Filtration, reabsorption, and secretion are the three main activities they perform.
Ques. What are the 4 parts of the nephron?
Ans. The components of a single nephron include: Renal corpuscle, the Proximal convoluted tubule, the Loop of Henle, the Distal convoluted tubule.
Ques. What does the loop of Henle do?
Ans. The primary purpose of the Henle loop is to recover water and sodium chloride from urine. This function enables the creation of urine that is significantly more concentrated than blood, hence reducing the amount of water required for survival.
Ques. What is Bowman’s capsule?
Ans. Bowman’s capsule is a sack-like portion of the nephron that surrounds the glomerulus. Bowman’s capsule encloses “Bowman’s space,” which is continuous with the proximal convoluted tubule of the nephron and constitutes the start of the urinary space.